참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxybromide | HCID 24613 | — |
| 반응물 | 8-Bromo-1,2-dihydroquinolin-2-one | HCID 10933094 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2,8-Dibromoquinoline | HCID 45925951 | 80% |
반응 단계
A mixture of 8-bromoquinolin-2(1H)-one (5 g, 22 mmol) and phosphoryl tribromide (13 g, 45 mmol) was heated to 140° C. for three hours. The resulting mixture was poured onto 100 g of ice and 100 ml water. The mixture was stirred for 1 hour and the resulting solids were filtered to yield the title compound. (5.1 g, 80% yield) MS APCI (+) 286, 288, and 290 (M+1 of each isotope combination) detected.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08138181B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_03 |
|---|
| ORD ID | ord-f295163c5eb74fd1b7e6855b6c336ce1 |
|---|
| 출처 메모 | uspto-grants-2012_03 |
|---|
