HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1095699Generated: October 30, 2026
Sodium ethanethiolate → 2-(7-(2-Methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-4-(oxazol-5-yl)quinolin-8-ol
https://huagongshe.com/reaction/1095699
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium ethanethiolate | HCID 4459711 | — |
| Reactant | 5-(8-Methoxy-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-4-yl)oxazole | HCID 66781947 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(7-(2-Methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-4-(oxazol-5-yl)quinolin-8-ol | HCID 66781398 | 39% |
Reaction Steps
To 5-(8-methoxy-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-4-yl)oxazole (80 mg, 0.19 mmol) in DMF (3 mL) was added sodium ethanethiolate (162 mg, 1.9 mmol). The reaction vial was sealed and heated to 150° C. for 2 hours. The reaction was then cooled to ambient temperature and concentrated. The residue was purified by flash column chromatography (DCM/MeOH 10:1) providing the desired product (39%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08138181B2 |
|---|
| Source dataset | uspto-grants-2012_03 |
|---|
| ORD ID | ord-273bc1942962477fa777aaa4a5af44fa |
|---|
| Source note | uspto-grants-2012_03 |
|---|
