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HRID1095700

反应详情

EQUATION

反应方程式

HRID 1095700 的结构方程式

REACTANTS

反应物

4
结构：O=C([O-])[O-].[Cs+].[Cs+]
HCID10796

Cesium carbonate

CCs2O3

结构：O=C([O-])N1CCCCC1
HCID21874245

未命名化合物

结构：CC(C)(C)OC(=O)N1CC[C@H](OS(C)(=O)=O)[C@H](F)C1
HCID52324470

1-Piperidinecarboxylic acid, 3-fluoro-4-[(methylsulfonyl)oxy]-, 1,1-dimethylethyl ester, (3R,4S)-

C11H20FNO5S

结构：COCCOc1ccn2c(-c3cc(-c4cnco4)c4cccc(O)c4n3)cnc2c1
HCID66781398

未命名化合物

PRODUCTS

生成物

1
结构：COCCOc1ccn2c(-c3cc(-c4cnco4)c4cccc(O[C@@H]5CCNC[C@H]5F)c4n3)cnc2c1
HCID66782186

未命名化合物

收率 3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)N(C)C
溶剂HCID31374

Dimethylacetamide

C4H9NO

CONDITIONS

反应条件

温度
106 °C

PROCEDURE

实验过程

Preparation of (trans)tert-butyl 3-fluoro-4-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-4-oxazol-5-yl)quinolin-8-yloxy)piperidine-1-carboxylate: To 2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-4-(oxazol-5-yl)quinolin-8-ol (9 mg, 0.02 mmol) in DMA (2 mL) was added (cis)-tert-butyl 3-fluoro-4-(methylsulfonyloxy)piperidine-1-carboxylate (13 mg, 0.04 mmol) and Cs2CO3 (22 mg, 0.07 mmol). The reaction vial was sealed and heated to 106° C. for 4 hours. The reaction was cooled to ambient temperature and concentrated. The crude residue was purified by flash column chromatography (DCM/MeOH 10:1) providing the desired product (3%).

WORKUP

后处理

  1. customThe reaction
  2. customvial was sealed
  3. temperatureThe reaction was cooled to ambient temperature
  4. concentrationconcentrated
  5. customThe crude residue was purified by flash column chromatography (DCM/MeOH 10:1)