Trifluoroacetic acid → HCID 66782087, compound

Participants

Reaction Steps

A solution of cis-naphthalen-2-ylmethyl 3-fluoro-4-(2-(7-(pyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yloxy)pyrrolidine-1-carboxylate (2.0 mg, 0.003 mmol) in 1 ml DCM was cooled to 0° C. and 1 ml TFA was added. The mixture was stirred for 16 hours at ambient temperature and then concentrated. The residue was purified by preparative TLC, eluting with 15% MeOH/0.5% NE4OH in chloroform to give the title compound as a film (1.1 mg, 78% yield). MS APCI (+) m/z 426.2 (M+1) detected.

Provenance & Evidence