HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-3,5-dimethylpyridine → 8-(Cyclopentyloxy)-4-(3,5-dimethylpyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-3,5-dimethylpyridine | HCID 22323246 | — |
| Reactant | 4-amino-8-(cyclopentyloxy)-7-methoxyquinolin-2(1H)-one | HCID 66781293 | — |
| Product | 8-(Cyclopentyloxy)-4-(3,5-dimethylpyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one | HCID 24851914 | — |
Reaction Steps
The title compound was prepared from 4-bromo-3,5-dimethylpyridine and 4-amino-8-(cyclopentyloxy)-7-methoxyquinolin-2(1H)-one (Example 1, Step 6) following the procedure outlined in Example 8. 1H NMR (400 MHz, DMSO-d6): δ 9.08 (s, 1H), 8.44 (s, 1H), 8.40 (s, 2H), 7.88 (d, 1H), 7.03 (d, 1H), 4.96 (m, 1H), 4.51 (s, 1H), 3.90 (s, 3H), 2.13 (s, 6H), 1.80-1.54 (m, 8H); MS (ESI): 380.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138205B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-ba6e48cbfef94cd695eea470b56c2b8e |
| Source note | uspto-grants-2012_03 |