HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(cyclopropylmethoxy)-4-methoxy-2-nitrobenzoate → Methyl 2-amino-3-(cyclopropylmethoxy)-4-methoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(cyclopropylmethoxy)-4-methoxy-2-nitrobenzoate | HCID 53442000 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-amino-3-(cyclopropylmethoxy)-4-methoxybenzoate | HCID 53441652 | 95.2% |
Reaction Steps
A mixture of methyl 3-(cyclopropylmethoxy)-4-methoxy-2-nitrobenzoate (128 g, 0.46 mol), 10% Pd/C (110 g, 103 mmol Pd), and methanol (1 L) was stirred overnight at room temperature under an atmosphere of H2. The resulting mixture was filtered and concentrated to give 110 g of methyl 2-amino-3-(cyclopropylmethoxy)-4-methoxybenzoate as a white solid. MS (ESI): 252.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138205B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-220d446a98604ac2b7522953fb9228b4 |
| Source note | uspto-grants-2012_03 |