Morpholine → 1218778-89-2

Participants

Role	Name	HCID	Charge
Reactant	Morpholine	HCID 8083	—
Reactant	8-(6-chlorohexyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one	HCID 59268117	—
Product	1218778-89-2	HCID 51347589	—

Reaction Steps

The title compound was prepared from 8-(6-chlorohexyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one (Intermediate 4) and morpholine following the procedure outlined in Example 15. 1H NMR (400 MHz, DMSO-d6): δ 9.97 (s, 1H), 8.83 (s, 1H), 8.77 (s, 2H), 7.88 (d, 1H), 7.04 (d, 1H), 4.79 (s, 1H), 3.97 (t, 2H), 3.79 (s, 3H), 3.52 (app t, 4H), 2.29 (br, 4H), 2.22 (t, 2H), 1.74 (m, 2H), 1.39 (m, 4H), 1.30 (m, 2H); MS (ESI): 521.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08138205B2
Source dataset	uspto-grants-2012_03
ORD ID	ord-a5742bbc7d2e4074829e9f369f37cc35
Source note	uspto-grants-2012_03