HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,6-Dibromohexane → HCID 66781767, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,6-Dibromohexane | HCID 12368 | — |
| Reactant | 8-(6-chlorohexyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one | HCID 59268117 | — |
| Reactant | 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxyquinolin-2(1H)-one | HCID 59268118 | — |
| Product | HCID 66781767 | HCID 66781767 | — |
Reaction Steps
8-(6-Bromohexyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one was prepared from 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxyquinolin-2(1H)-one (Intermediate 3) and 1,6-dibromohexane following the procedure outlined for Intermediate 4 (modifications: 1.3 equiv NaH and 2.5 equiv of dibromide used; reaction run at room temperature). MS (ESI): 514.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138205B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-1e382ce3c2554664900f41fa82fae0fe |
| Source note | uspto-grants-2012_03 |