1,3-Dibromopropane → HCID 66780790, compound

Participants

Role	Name	HCID	Charge
Reactant	1,3-Dibromopropane	HCID 8001	—
Reactant	8-(6-chlorohexyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one	HCID 59268117	—
Reactant	4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxyquinolin-2(1H)-one	HCID 59268118	—
Product	HCID 66780790	HCID 66780790	—

Reaction Steps

8-(3-Bromopropoxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one was prepared from 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxyquinolin-2(1H)-one (Intermediate 3) and 1,3-dibromopropane following the procedure outlined for Intermediate 4 (modifications: 1.0 equiv KHMDS and 5.0 equiv of dibromide used; reaction run at room temperature). MS (ESI): 472.1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08138205B2
Source dataset	uspto-grants-2012_03
ORD ID	ord-9e9f0fb60e8548fdb486961ea5a4b3fa
Source note	uspto-grants-2012_03