1-Methylpiperazine → HCID 53346362, compound

Participants

Reaction Steps

The title compound was prepared from 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxyquinolin-2(1H)-one (Intermediate 3), 1,8-dibromoocttane, and 1-methylpiperazine following the procedures outlined for Intermediate 4 (modifications: NMP used as solvent and 5.0 equiv of dibromide used) and Example 18, Step 2. 1H NMR (400 MHz, DMSO-d6, bis HCl salt): δ 11.89 (br, 2H), 10.49 (s, 1H), 9.24 (s, 1H), 8.81 (s, 2H), 8.01 (d, 1H), 7.16 (d, 1H), 4.97 (s, 1H), 4.01 (t, 2H), 3.94 (s, 3H), 3.82-3.20 (br m, 8H), 3.10 (m, 2H), 2.81 (s, 3H), 1.84-1.66 (m, 4H), 1.46-1.26 (m, 8H); MS (ESI): 562.3.

Provenance & Evidence