HCID 66783705, compound → HCID 66784399, compound

HRID 1095822Notes

Reaction equation

HRID 1095822 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:22][CH2:21][C:11]3([O:16][CH2:15][C:14](=[O:17])[N:13]([CH:18]([CH3:20])[CH3:19])[CH2:12]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Br.Br[CH2:25][CH2:26][CH2:27][N:28]1[CH2:32][CH2:31][CH2:30][C@H:29]1[CH3:33]>>[CH:18]([N:13]1[CH2:12][C:11]2([CH2:21][CH2:22][N:8]([C:5]3[CH:6]=[CH:7][C:2]([O:1][CH2:25][CH2:26][CH2:27][N:28]4[CH2:32][CH2:31][CH2:30][C@H:29]4[CH3:33])=[CH:3][CH:4]=3)[CH2:9][CH2:10]2)[O:16][CH2:15][C:14]1=[O:17])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 66783705HCID 66783705, compoundHCID 66784433HCID 66784433, compound

Product 1

HCID 66784399HCID 66784399, compound

Procedure

The entitled compound was obtained as a white solid according to the same method as in Example 4-(c) or according to a method similar to it but using 9-(4-hydroxyphenyl)-4-isopropyl-1-oxa-4,9-diazaspiro[5,5]undecan-3-one obtained in Example 4-10-(b) and (2R)-1-(3-bromopropyl)-2-methylpyrrolidine hydrobromide produced in Reference Example 4-2.

Workup

  1. customThe entitled compound was obtained as a white solid
  2. customproduced in Reference Example 4-2

Sources & evidence

ORD record
ord-b2b7c15ad3fd41a38d3acd16e077cf93
Source dataset
uspto-grants-2012_03
Patent number
US08138206B2

Reaction notes

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