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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1095824Generated: November 3, 2026

1-(3-Bromopropyl)pyrrolidine hydrobromide → 4-Benzyl-9-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1-oxa-4,9-diazaspiro[5,5]undecan-3-one

https://huagongshe.com/reaction/1095824

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3-Bromopropyl)pyrrolidine hydrobromideHCID 20135920—
Reactant4-Benzyl-9-(4-hydroxyphenyl)-1-oxa-4,9-diazaspiro[5,5]undecan-3-oneHCID 66783428—
Product4-Benzyl-9-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1-oxa-4,9-diazaspiro[5,5]undecan-3-oneHCID 66783910—

Reaction Steps

The entitled compound was obtained as a yellow solid, according to the same method as in Example 4-(c) or according to a method similar to it but using 4-benzyl-9-(4-hydroxyphenyl)-1-oxa-4,9-diazaspiro[5,5]undecan-3-one produced in Example 4-19-(b) and 1-(3-bromopropyl)pyrrolidine hydrobromide produced according to a method described in a patent (U.S. Pat. No. 4,751,302).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08138206B2
Source datasetuspto-grants-2012_03
ORD IDord-02897a9f08dc47c5a61ccbb81e3eea0d
Source noteuspto-grants-2012_03