Sodium Hydroxide → HCID 66784058, compound

Participants

Reaction Steps

The methoxy compound (205 mg, 0.553 mmol) obtained in (a) was dissolved in chloroform, and at 0° C., 1.0 M boron tribromide/dichloromethane solution (2.2 ml, 2.2 mmol) was dropwise added thereto, and this was stirred overnight at room temperature. At 0° C., the reaction solution was neutralized by adding aqueous 2 N sodium hydroxide solution thereto, and extracted with chloroform, and the organic layer was washed with saturated saline. The organic layer was dried with sodium sulfate, and the solvent was evaporated off under reduced pressure to obtain the phenol compound as a crude product (165 mg, 84%).

Provenance & Evidence