反应详情

Starting with [4-(3-benzoylamino-benzenesulfonylamino)-4,5,6,7-tetrahydro-indazol-1-yl]-acetic acid ethyl ester using the method analogous to the one described for example 1-1a, [4-(3-benzoylamino-benzenesulfonylamino)-6,7-dihydro-indazol-1-yl]-acetic acid (11.0 mg, 50%) as a white solid. 1H NMR (400 MHz, CD3OD) δ ppm 8.48 (s, 1 H), 7.98 (m, 3 H), 7.73-7.52 (m, 5 H), 6.79 (s, 1 H), 4.78 (s, 2 H), 4.42 (s, 1 H), 2.55 (m, 2 H), 2.04-1.77 (m, 4 H). MS cald. for C22H22N4O5S 454, obsd. (ESI+) [(M+H)+] 455.