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Potassium Carbonate → 4-(2-{3-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenoxy}-ethoxy)-benzoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 4-(2-bromoethoxy)benzoate | HCID 1898264 | — |
| 反応物 | 3-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol | HCID 57421231 | — |
| 生成物 | 4-(2-{3-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenoxy}-ethoxy)-benzoic acid methyl ester | HCID 46940640 | — |
反応手順
In analogy to Example 1, step 7, 3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol (Example 1, step 6) was reacted with methyl 4-(2-bromoethoxy)benzenecarboxylate and potassium carbonate to give the title compound as a colorless viscous oil. MS (m/e)=524.9 [M+H+].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08138189B2 |
| 出典データセット | uspto-grants-2012_03 |
| ORD ID | ord-8c9453bc5a184608a0dccf0838d4d53f |
| 出典メモ | uspto-grants-2012_03 |