HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-amino-1,3-oxazole-4-carboxylate → HCID 86645945, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-amino-1,3-oxazole-4-carboxylate | HCID 319549 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzoic acid | HCID 57421268 | — |
| Product | HCID 86645945 | HCID 86645945 | — |
Reaction Steps
In analogy to Example 26, step 4, 3-chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzoic acid (Example 26, step 3), was reacted with 2-aminooxazol-4-carboxylic acid ethylester and HBTU at r.t. 17 h to give the title compound as a white solid. MS (m/e)=532.3 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138189B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-c99002d471a747fc818f0b6ac3818b13 |
| Source note | uspto-grants-2012_03 |