HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(aminomethyl)benzoate hydrochloride → HCID 46941179, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(aminomethyl)benzoate hydrochloride | HCID 2729253 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzoic acid | HCID 57421268 | — |
| Product | HCID 46941179 | HCID 46941179 | — |
Reaction Steps
In analogy to Example 26, step 4, 3-chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzoic acid, Example 26, step 3, was reacted with methyl-4-(aminomethyl)benzoate hydrochloride and HBTU at 80° C., 2 h to give the title compound as a white solid. MS (m/e)=541.2 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138189B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-e02dbadd1be64e9c90733ade68b46171 |
| Source note | uspto-grants-2012_03 |