HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic acid, 3-amino-, methyl ester → HCID 46941258, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic acid, 3-amino-, methyl ester | HCID 78274 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzoic acid | HCID 57421268 | — |
| Product | HCID 46941258 | HCID 46941258 | — |
Reaction Steps
In analogy to Example 26, step 4, 3-chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzoic acid, Example 26, step 3, was reacted with methyl-3-aminobenzoate and HBTU at 80° C. 4 h to give the title compound as a white solid. MS (m/e)=527.3 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138189B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-05cce307b7014d5b840cfac6414971c1 |
| Source note | uspto-grants-2012_03 |