Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → 6-{3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzoylamino}-pyridine-2-carboxylic acid methyl ester

Participants

Reaction Steps

In analogy to Example 26, step 4, 3-chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzoic acid (Example 26, step 3), was reacted with 6-aminopicolinic acid methyl ester and HBTU at 80° C. 17 h to give the title compound as a white solid. MS (m/e)=528.3 [M+H+].

Provenance & Evidence