Methyl morpholine oxide → HCID 66699032, Verbindung

Beteiligte Stoffe

Reaktionsschritte

4-Methyl-morpholine-4-oxide (136 mg) and tetrapropylammonium perruthenate (18 mg) were added to a solution of 4-{3-chloro-4-[2-hydroxy-1-methyl-2-(2-methyl-pyridin-4-yl)-ethyl]-phenoxy}-benzonitrile (190 mg, 0.5 mmol) in DCM (5 ml) with 3A molecular sieves. The mixture was stirred for 2 h at room temperature, filtered and concentrated to an oil. The residue was purified by flash chromatography (SiO2, 0 to 30% EtOAc/heptane) to give the title compound (80 mg) as a light yellow solid. MS (m/e)=377.3 [M+H+].

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