Methyl 5-(bromomethyl)pyrazine-2-carboxylate → 5-{3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxymethyl}-pyrazine-2-carboxylic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Methyl 5-(bromomethyl)pyrazine-2-carboxylate	HCID 21973569	—
Reactant	3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol	HCID 57421264	—
Product	5-{3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxymethyl}-pyrazine-2-carboxylic acid methyl ester	HCID 59508579	—

Reaction Steps

The title compound was prepared in analogy to Example 101 from 3-chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol (obtained in Example 19, step 5) and 5-bromomethyl-pyrazine-2-carboxylic acid methyl ester [CAS Reg. No. 193966-70-0]. MS (m/e)=516.3 [MH+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08138189B2
Source dataset	uspto-grants-2012_03
ORD ID	ord-d5f8bc2308204ef7ba71ead52cf0981f
Source note	uspto-grants-2012_03