Methyl 6-chloropyridazine-3-carboxylate → HCID 72310573, compound

HRID 1095944Notes

Reaction equation

HRID 1095944 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[CH:10]([CH3:24])[C:11]([C:17]1[CH:22]=[CH:21][N:20]=[C:19]([Cl:23])[CH:18]=1)([OH:16])[C:12]([F:15])([F:14])[F:13].[CH3:25][O:26][C:27]([C:29]1[N:30]=[N:31][C:32](Cl)=[CH:33][CH:34]=1)=[O:28]>>[CH3:25][O:26][C:27]([C:29]1[N:30]=[N:31][C:32]([O:9][CH2:8][C:6]2[CH:5]=[CH:4][C:3]([CH:10]([CH3:24])[C:11]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([Cl:23])[CH:18]=3)([OH:16])[C:12]([F:15])([F:14])[F:13])=[C:2]([Cl:1])[CH:7]=2)=[CH:33][CH:34]=1)=[O:28]

Participants

3

Reactant 2

HCID 12379801Methyl 6-chloropyridazine-3-carboxylateHCID 252544493-(2-Chloro-4-hydroxymethyl-phenyl)-2-(2-chloro-pyridin-4-yl)-1,1,1-trifluoro-butan-2-ol

Product 1

HCID 72310573HCID 72310573, compound

Procedure

The title compound was prepared in analogy to Example 93, step 7 from 3-(2-chloro-4-hydroxymethyl-phenyl)-2-(2-chloro-pyridin-4-yl)-1,1,1-trifluoro-butan-2-ol (obtained in Example 120, stepl) by alkylation with methyl-6-chloropyridazine-3-carboxylate [CAS Reg. No. 65202-50-8]. MS (m/e)=516.1 [MH+].

Sources & evidence

ORD record
ord-edae84da7c264e9388b8433ccf61d194
Source dataset
uspto-grants-2012_03
Patent number
US08138189B2

Reaction notes

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