HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 6-chloropyridazine-3-carboxylate → 6-{4-Chloro-3-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxy}-pyridazine-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 6-chloropyridazine-3-carboxylate | HCID 12379801 | — |
| Reactant | 4-Chloro-3-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol | HCID 25254603 | — |
| Product | 6-{4-Chloro-3-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxy}-pyridazine-3-carboxylic acid methyl ester | HCID 72310559 | — |
Reaction Steps
The title compound was prepared in analogy to Example 132 from 4-chloro-3-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol (obtained in Example 130, step 7) with methyl-6-chloropyridazine-3-carboxylate [CAS Reg. No.65202-50-8]. MS (m/e)=502.1 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138189B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-65710148227f480593cb514d6b2c200b |
| Source note | uspto-grants-2012_03 |