HRID1095980

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7748

Ethyl bromoacetate

C4H7BrO2

HCID10796

Cesium carbonate

CCs2O3

结构：CC(c1ccc(Oc2ccc(F)c(O)c2)cc1Cl)C(O)(c1ccc(=O)n(C)c1)C(F)(F)F

HCID57421317

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)COc1cc(Oc2ccc(C(C)C(O)(c3ccc(=O)n(C)c3)C(F)(F)F)c(Cl)c2)ccc1F

HCID66782632

未命名化合物

PROCEDURE

实验过程

In analogy to Example 147, step 6, 5-{2-[2-chloro-4-(4-fluoro-3-hydroxy-phenoxy)-phenyl]-1-hydroxy-1-trifluoromethyl-propyl}-1-methyl-1H-pyridin-2-one was reacted with ethylbromoacetate and cesium carbonate to give the title compound as a colorless solid. MS (m/e)=558.2 [M+H+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1ecc6fac971d4419a58f9035b20fcf76
来源数据集: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08138189B2
来源说明: uspto-grants-2012_03

反应 SMILES

[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[C:11]([OH:16])[CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH:17]([CH3:32])[C:18]([C:24]1[CH:25]=[CH:26][C:27](=[O:31])[N:28]([CH3:30])[CH:29]=1)([OH:23])[C:19]([F:22])([F:21])[F:20].[CH2:33]([O:35][C:36](=[O:39])[CH2:37]Br)[CH3:34].C(=O)([O-])[O-].[Cs+].[Cs+]>>[CH2:33]([O:35][C:36](=[O:39])[CH2:37][O:16][C:11]1[CH:10]=[C:9]([O:8][C:6]2[CH:5]=[CH:4][C:3]([CH:17]([CH3:32])[C:18]([OH:23])([C:24]3[CH:25]=[CH:26][C:27](=[O:31])[N:28]([CH3:30])[CH:29]=3)[C:19]([F:22])([F:20])[F:21])=[C:2]([Cl:1])[CH:7]=2)[CH:14]=[CH:13][C:12]=1[F:15])[CH3:34]