Methyl iodide → HCID 66699491, compound

HRID 1095991Notes

Reaction equation

HRID 1095991 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:11]2[CH:12]=[N:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=2)=[O:10])=[C:4]([Cl:19])[CH:3]=1.I[CH3:21]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:21])[C:9]([C:11]2[CH:12]=[N:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=2)=[O:10])=[C:4]([Cl:19])[CH:3]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 66699181HCID 66699181, compound

Product 1

HCID 66699491HCID 66699491, compound

Procedure

In analogy to Example 165, steps 2 and 3, 2-(4-bromo-2-chloro-phenyl)-1-(6-methoxy-pyridin-3-yl)-ethanone was alkylated with iodomethane to give 2-(4-bromo-2-chloro-phenyl)-1-(6-methoxy-pyridin-3-yl)-propan-1-one which was further converted to the title compound. Colorless Oil. MS (m/e)=424.0 [M+H+].

Sources & evidence

ORD record
ord-b0de58f0e76844faa55e2cf519513a51
Source dataset
uspto-grants-2012_03
Patent number
US08138189B2

Reaction notes

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