Tetramethylammonium fluoride → HCID 57421325, compound

HRID 1096013Notes

Reaction equation

HRID 1096013 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][C:3]=1[CH:11]([CH3:22])[C:12]([C:14]1[CH:15]=[CH:16][C:17](=[O:21])[N:18]([CH3:20])[CH:19]=1)=[O:13].[F:23][C:24]([Si](C)(C)C)([F:26])[F:25].[F-].C[N+](C)(C)C>>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][C:3]=1[CH:11]([CH3:22])[C:12]([C:14]1[CH:15]=[CH:16][C:17](=[O:21])[N:18]([CH3:20])[CH:19]=1)([OH:13])[C:24]([F:26])([F:25])[F:23]

Participants

4

Reactant 3

HCID 67803Tetramethylammonium fluorideHCID 552549(Trifluoromethyl)trimethylsilaneHCID 66699447HCID 66699447, compound

Product 1

HCID 57421325HCID 57421325, compound

Procedure

In analogy to Example 165, step 3, 5-[2-(2,3-dichloro-4-methoxy-phenyl)-propionyl]-1-methyl-1H-pyridin-2-one was reacted with (trifluoromethyl)trimethylsilane and tetramethylammonium fluoride to give the title compound as a colorless solid. MS (m/e, ISP neg. ion.)=408.2 [M−H+].

Sources & evidence

ORD record
ord-4945572f24c04212bd91940f7a5816ce
Source dataset
uspto-grants-2012_03
Patent number
US08138189B2

Reaction notes

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