Boron tribromide → HCID 66699141, compound

HRID 1096017Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([O:8]C)[C:5]([F:10])=[CH:4][C:3]=1[CH:11]([CH3:26])[C:12]([C:18]1[CH:19]=[CH:20][C:21](=[O:25])[N:22]([CH3:24])[CH:23]=1)([OH:17])[C:13]([F:16])([F:15])[F:14].B(Br)(Br)Br>>[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[C:5]([F:10])=[CH:4][C:3]=1[CH:11]([CH3:26])[C:12]([C:18]1[CH:19]=[CH:20][C:21](=[O:25])[N:22]([CH3:24])[CH:23]=1)([OH:17])[C:13]([F:16])([F:15])[F:14]

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 57421327HCID 57421327, compound

Product 1

HCID 66699141HCID 66699141, compound

Procedure

In analogy to Example 147, step 5, 5-[2-(2-chloro-5-fluoro-4-methoxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one was reacted with BBr3 to give the title compound as a light yellow foam. MS (m/e)=380.3 [M+H+].

Sources & evidence

ORD record: ord-eb87134677a14d7c9b6faf16ce60a043
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08138189B2

Reaction notes

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