HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 66699529, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3,4-Difluorobenzonitrile | HCID 587203 | — |
| Reactant | 5-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1,3-dimethyl-1H-pyridin-2-one | HCID 66699301 | — |
| Product | HCID 66699529 | HCID 66699529 | — |
Reaction Steps
In analogy to Example 156, step 1, 5-[2-(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1,3-dimethyl-1H-pyridin-2-one (Example 203, step 5) was reacted with 3,4-difluorobenzonitrile and cesium carbonate to give the title compound as a colorless solid. MS (m/e)=495.2 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138189B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-33fb1d149d2a48a49cf939e0d6cd7ed6 |
| Source note | uspto-grants-2012_03 |