HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dabco → HCID 72310567, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dabco | HCID 9237 | — |
| Reactant | Methyl 6-chloro-4-(trifluoromethyl)nicotinate | HCID 2775340 | — |
| Reactant | HCID 66699206 | HCID 66699206 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 72310567 | HCID 72310567 | — |
Reaction Steps
In analogy to Example 163, 3-chloro-5-[2-(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one (Example 221, step 5) was reacted with methyl-6-chloro-4-(trifluoromethyl)-nicotinate in the presence of triethylamine and 1,4-diazabicyclo[2.2.2]octane to give the title compound as an off-white solid. MS (m/e)=599.1 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138189B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-3a23fb98cbab48e3beb4d407eee858e2 |
| Source note | uspto-grants-2012_03 |