Methyl 6-chloropyridine-3-carboxylate → HCID 66699402, compound

HRID 1096041Notes

Reaction equation

HRID 1096041 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:24])[C:10]([C:16]1[N:20]([CH3:21])[C:19]([C:22]#[N:23])=[CH:18][CH:17]=1)([OH:15])[C:11]([F:14])([F:13])[F:12].Cl[C:26]1[CH:35]=[CH:34][C:29]([C:30]([O:32]C)=[O:31])=[CH:28][N:27]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[CH:9]([CH3:24])[C:10]([C:16]1[N:20]([CH3:21])[C:19]([C:22]#[N:23])=[CH:18][CH:17]=1)([OH:15])[C:11]([F:14])([F:13])[F:12])[O:8][C:26]1[CH:35]=[CH:34][C:29]([C:30]([OH:32])=[O:31])=[CH:28][N:27]=1

Participants

3

Reactant 2

HCID 254249Methyl 6-chloropyridine-3-carboxylateHCID 66699319HCID 66699319, compound

Product 1

HCID 66699402HCID 66699402, compound

Procedure

The title compound was prepared in analogy to Example 227, step 3, from 5-[2-(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyrrole-2-carbonitrile (Example 232 step 2) and methyl 6-chloronicotinate (CAS Reg. No. 73781-91-6). White foam. MS (m/e, ISP neg. ion)=477.9 [M−H+].

Sources & evidence

ORD record
ord-0483abc6afc6414cade4329bdb3f037f
Source dataset
uspto-grants-2012_03
Patent number
US08138189B2

Reaction notes

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