Hydrochloric Acid → HCID 66783111, compound

Participants

Reaction Steps

5-{2,3-Dichloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-propyl]-phenoxy}-pyrazine-2-carboxylic acid methyl ester (Example 237; 160 mg, 0.3 mmol) in 1.2 ml THF was treated with 0.6 ml 1N aqueous NaOH and stirred at rt for 2 h. After addition of 1 ml 1N HCl, the reaction mixture was extracted twice with ethyl acetate and the combined organic phases were washed with water and brine, dried over magnesium sulfate, filtered off and concentrated in vacuo to give 156 mg of the title compound as a white solid. MS (M+H+)=518.1

Provenance & Evidence