HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dabco → HCID 72310593, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dabco | HCID 9237 | — |
| Reactant | 5-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1,3-dimethyl-1H-pyridin-2-one | HCID 66699301 | — |
| Reactant | HCID 86313418 | HCID 86313418 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 72310593 | HCID 72310593 | — |
Reaction Steps
In analogy to Example 163, 5-[2-(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1,3-dimethyl-1H-pyridin-2-one (Example 203, step 5) was reacted with 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate in the presence of triethylamine and 1,4-diazabicyclo[2.2.2]octane to give the title compound as a colorless solid. MS (m/e)=580.2 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138189B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-c9a2f717620841c3857058e9b8881327 |
| Source note | uspto-grants-2012_03 |