Sodium Carbonate → HCID 24795031, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-(3-oxo-2,3-dihydro-1H-inden-5-yl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide (100 mg, 0.26 mmol), 1-methylpiperazine (0.28 ml, 2.6 mmol) and titanium (IV) isopropoxide (0.1 ml, 0.33 mmol) was heated at 50° C. for 30 min. The material was dissolved in ethanol and sodium borohydride (11 mg, 0.29 mmol) was added. After stirring at reflux for 3 hours, 2N sodium carbonate was added. The mixture was filtered and the filtrate was concentrated in vacuo. The resulting crude was purified by chromatography on silica gel, using as an eluent mixtures of methylene chloride/methanol/ammonia yielding 80 mg (65%) of N-[3-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-inden-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide as a solid.

Provenance & Evidence