N-(dimethoxymethyl)-N-methylethanamine → HCID 58283707, compound

HRID 1096055Notes

Reaction equation

HRID 1096055 reaction equation
[NH2:1][C:2]1[C:23]([CH3:24])=[CH:22][C:5]([O:6][C:7]2[S:11][N:10]=[C:9]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:8]=2[C:20]#[N:21])=[C:4]([CH3:25])[CH:3]=1.CO[CH:28](OC)[N:29]([CH3:32])[CH2:30][CH3:31]>C1(C)C=CC=CC=1>[Cl:19][C:16]1[CH:15]=[CH:14][C:13]([CH2:12][C:9]2[C:8]([C:20]#[N:21])=[C:7]([O:6][C:5]3[C:4]([CH3:25])=[CH:3][C:2]([N:1]=[CH:28][N:29]([CH2:30][CH3:31])[CH3:32])=[C:23]([CH3:24])[CH:22]=3)[S:11][N:10]=2)=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 23017846N-(dimethoxymethyl)-N-methylethanamine2×HCID 58283715HCID 58283715, compound

Product 1

HCID 58283707HCID 58283707, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 1.80 g (4.87 mmol) of 5-(4-amino-2,5-dimethylphenoxy)-3-(4-chlorobenzyl)isothiazole-4-carbonitrile and 0.91 g (6.8 mmol) of N-(dimethoxymethyl)-N-methylethanamine in 60 ml of toluene is stirred at 80° C. for 22 h. Another 0.91 g (6.8 mmol) of N-(dimethoxymethyl)-N-methylethanamine is added, and the solution is then stirred for a further 22 h.

Sources & evidence

ORD record
ord-4d59c94641194a2e8bd99115014df466
Source dataset
uspto-grants-2012_03
Patent number
US08138211B2

Reaction notes

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