Potassium;tri(butan-2-yl)boranuide → HCID 66782970, compound

Participants

Reaction Steps

To a solution of (S)-1-benzyl-5-methyl-piperidin-3-one (1.1 g, 5 mmol) in dry THF (15 ml) at −78° C. was added K-selectride (10.8 ml, 11 mmol, 1 M solution in THF). After 2 h at −78° C. a few drops of water were cautiously added, the reaction allowed to reach RT, the THF removed by evaporation and the residue the residue redissolved in CH2Cl2, washed with sat. aq. NaHCO3 solution, dried (Na2SO4) and concentrated. Purification by flash column chromatography (EtOAc/heptane 1:4) afforded the titled product as a crystalline solid (0.9 g, 43%). MS (ISP)=204.3 (M+H)+.

Provenance & Evidence