HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4S)-6-Azaspiro[2.5]octan-4-ol → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4S)-6-Azaspiro[2.5]octan-4-ol | HCID 44541813 | — |
| Reactant | (S)-2-[4-(3,4-dichloro-phenyl)-7-oxo-[1,4]diazepan-1-yl]-4-oxo-butyric acid methyl ester | HCID 86638379 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (S)-2-[4-(3,4-Dichloro-phenyl)-7-oxo-[1,4]diazepan-1-yl]-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-butyric Acid methyl ester | HCID 59159299 | — |
Reaction Steps
In analogy to the procedure described for example 1E, (S)-2-[4-(3,4-dichloro-phenyl)-7-oxo-[1,4]diazepan-1-yl]-4-oxo-butyric acid methyl ester and (S)-6-aza-spiro[2.5]octan-4-ol; hydrochloride (intermediate 2) gave the title compound in 60% yield as light yellow foam. MS: 484.3 (MH+, 2Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138175B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-5459698adcba4c09b0eb759f6bfeecae |
| Source note | uspto-grants-2012_03 |