(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride → HCID 59159284, compound

HRID 1096206Notes

Reaction equation

HRID 1096206 reaction equation
[CH3:1][O:2][C:3](=[O:26])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH:6]=O.Cl.[CH2:28]1[C:30]2([CH2:35][CH2:34][NH:33][CH2:32][C@H:31]2[OH:36])[CH2:29]1>>[CH3:1][O:2][C:3](=[O:26])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:23])[F:24])[CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH2:6][N:33]1[CH2:34][CH2:35][C:30]2([CH2:29][CH2:28]2)[C@H:31]([OH:36])[CH2:32]1

Participants

3

Reactant 2

HCID 44541812(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride2×HCID 86638381(S)-4-Oxo-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyric acid methyl ester

Product 1

HCID 59159284HCID 59159284, compoundYield 70%

Procedure

In analogy to the procedure described in example 1K, (S)-4-oxo-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyric acid methyl ester and (S)-6-aza-spiro[2.5]octan-4-ol hydrochloride (intermediate 2) gave the pure title compound in 70% yield as light yellow foam. MS: 484.4 (MH+).

Sources & evidence

ORD record
ord-ccdd2f18d7cf430981b2b226a1620168
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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