(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride → HCID 59159303, compound

HRID 1096210Notes

Reaction equation

HRID 1096210 reaction equation
[CH3:1][O:2][C:3](=[O:22])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH:6]=O.Cl.[CH2:24]1[C:26]2([CH2:31][CH2:30][NH:29][CH2:28][C@H:27]2[OH:32])[CH2:25]1>>[CH3:1][O:2][C:3](=[O:22])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH2:6][N:29]1[CH2:30][CH2:31][C:26]2([CH2:24][CH2:25]2)[C@H:27]([OH:32])[CH2:28]1

Participants

3

Reactant 2

HCID 44541812(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride2×HCID 86638383HCID 86638383, compound

Product 1

HCID 59159303HCID 59159303, compound

Procedure

In analogy to the procedure described in example 1K, (S)-4-oxo-2-(7-oxo-4-phenyl-[1,4]diazepan-1-yl)-butyric acid methyl ester and (S)-6-aza-spiro[2.5]octan-4-ol hydrochloride (intermediate 2) gave the title compound in 50% as light yellow foam. MS: 416.3 (MH+).

Sources & evidence

ORD record
ord-fa7b9cf9d9834111a1f06e8c6484eb57
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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