Dimethylamine → HCID 66783151, compound

HRID 1096216Notes

Reaction equation

HRID 1096216 reaction equation
[O:1]=[C:2]1[CH:6]([N:7]2[C:13](=[O:14])[CH2:12][CH2:11][N:10]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=3)[CH2:9][CH2:8]2)[CH2:5][CH2:4][O:3]1.[CH3:25][NH:26][CH3:27]>CCO>[OH:3][CH2:4][CH2:5][CH:6]([N:7]1[C:13](=[O:14])[CH2:12][CH2:11][N:10]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:23])([F:22])[F:24])[CH:16]=2)[CH2:9][CH2:8]1)[C:2]([N:26]([CH3:27])[CH3:25])=[O:1]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 66783513HCID 66783513, compound

Product 1

HCID 66783151HCID 66783151, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.26 g (0.76 mmol) of (rac)-4-(2-oxo-tetrahydro-furan-3-yl)-1-(3-trifluoromethyl-phenyl)-[1,4]diazepan-5-one (example 15C) was dissolved in 3 ml of EtOH and treated with 2.71 ml (15.19 mmol) of a solution of dimethylamine (5.6 M in EtOH). The reaction was stirred 20 h at RT, evaporated and re-evaporated with toluene to afford 0.31 g (quantitative) of the title compound as yellow oil. MS: 388.1 (MH+).

Workup

  1. customevaporated
  2. customre-evaporated with toluene

Sources & evidence

ORD record
ord-a1f6319a17f94dc6a09793b0b646533b
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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