(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride → HCID 45100808, compound

HRID 1096223Notes

Reaction equation

HRID 1096223 reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH:6]=O.Cl.[CH2:27]1[C:29]2([CH2:34][CH2:33][NH:32][CH2:31][C@H:30]2[OH:35])[CH2:28]1>>[OH:35][C@@H:30]1[CH2:31][N:32]([CH2:6][CH2:5][C@H:4]([N:8]2[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:23])[F:24])[CH:17]=3)[CH2:10][CH2:9]2)[CH2:3][O:2][CH3:1])[CH2:33][CH2:34][C:29]21[CH2:28][CH2:27]2

Participants

3

Reactant 2

HCID 44541812(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride2×HCID 86638387HCID 86638387, compound

Product 1

HCID 45100808HCID 45100808, compoundYield 58%

Procedure

In analogy to the procedure described in example 1K, (S)-4-methoxy-3-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyraldehyde and (S)-6-aza-spiro[2.5]octan-4-ol hydrochloride (intermediate 2) gave the title compound in 58% yield as light yellow foam. MS: 470.2 (MH+).

Sources & evidence

ORD record
ord-9b01cf1220564e569e52314c48051398
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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