HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Rac)-2,5-dibromo-n,n-dimethyl-pentanamide → (Rac)-5-bromo-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-pentanoic acid dimethylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Rac)-2,5-dibromo-n,n-dimethyl-pentanamide | HCID 20370625 | — |
| Reactant | 1-(3-Trifluoromethyl-phenyl)-[1,4]diazepan-5-one | HCID 21754509 | — |
| Product | (Rac)-5-bromo-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-pentanoic acid dimethylamide | HCID 66783239 | 73% |
Reaction Steps
In analogy to the procedure described in example 15B, 1-(3-trifluoromethyl-phenyl)-[1,4]diazepan-5-one (example 15 A) and (rac)-2,5-dibromo-N,N-dimethyl-pentanamide (intermediate 9) gave the title compound in 73% yield as light yellow oil. MS: 466.2 (1Br, MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138175B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-09c0c87da54a44cbb39bd98caa433680 |
| Source note | uspto-grants-2012_03 |