HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,5-dibromopentanoate → (Rac)-5-bromo-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,5-dibromopentanoate | HCID 10912698 | — |
| Reactant | 1-(3-Trifluoromethyl-phenyl)-[1,4]diazepan-5-one | HCID 21754509 | — |
| Product | (Rac)-5-bromo-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-pentanoic acid methyl ester | HCID 66783116 | 97% |
Reaction Steps
In analogy to the procedure described in example 15B, 1-(3-trifluoromethyl-phenyl)-[1,4]diazepan-5-one (example 15 A) and (rac)-2,5-dibromo-pentanoic acid methyl ester gave the title compound in 97% yield as yellow oil. MS: 453.1 (1Br, MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138175B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-d4a1d5ed96fc469894f746d739a888d7 |
| Source note | uspto-grants-2012_03 |