HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylpiperidin-4-ol → (Rac)-5-(4-hydroxy-4-methyl-piperidin-1-yl)-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylpiperidin-4-ol | HCID 15649174 | — |
| Reactant | (Rac)-5-bromo-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-pentanoic acid methyl ester | HCID 66783116 | — |
| Product | (Rac)-5-(4-hydroxy-4-methyl-piperidin-1-yl)-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-pentanoic acid methyl ester | HCID 59159271 | 73% |
Reaction Steps
In analogy to the procedure described in example 25B, (rac)-5-bromo-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-pentanoic acid methyl ester (example 26A) and 4-methyl-piperidin-4-ol (intermediate 8) gave the title compound in 73% yield as colorless oil. MS: 486.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138175B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-3bd2286e23284b57b5bd8fbb0a8bb610 |
| Source note | uspto-grants-2012_03 |