HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 59159290, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (Rac)-4-[1-hydroxymethyl-4-(4-hydroxy-4-methyl-piperidin-1-yl)-butyl]-1-(3-trifluoromethyl-phenyl)-[1,4]diazepan-5-one | HCID 59159282 | — |
| Product | HCID 59159290 | HCID 59159290 | 25% |
Reaction Steps
In analogy to the procedure described in example 23B, (rac)-4-[1-hydroxymethyl-4-(4-hydroxy-4-methyl-piperidin-1-yl)-butyl]-1-(3-trifluoromethyl-phenyl)-[1,4]diazepan-5-one was treated with iodomethane and NaH to give the title compound in 25% yield as colorless oil. MS: 472.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138175B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-9d50d6e0bfea4cff8091546bff72f4de |
| Source note | uspto-grants-2012_03 |