反应详情

To a solution of 4-but-3-enyl-1-(3-trifluoromethyl-phenyl)-[1,4]diazepan-5-one 0.09 g (0.03 mmol) in tBuOH:water (2 ml 1:1) was added potassium osmate dihydrate 0.001 g (0.001 mmol) and sodium periodate 0.13 g (0.1 mmol). The mixture was stirred for 1 h, then extracted with CH2Cl2, dried (Na2SO4) and concentrated. Purification by flash column chromatography (EtOAc:n-heptane 1:1→1:0) afforded the title compound 0.06 g (64%) as a brown gum. MS: 315.2 (MH+).

1. extractionextracted with CH2Cl2
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated
4. customPurification by flash column chromatography (EtOAc:n-heptane 1:1→1:0)