1-Iodo-3-(trifluoromethoxy)benzene → HCID 59159289, compound

HRID 1096248Notes

Reaction equation

HRID 1096248 reaction equation
[CH3:1][C@@H:2]1[CH2:8][N:7]([CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[C:6](=[O:18])[CH2:5][CH2:4][NH:3]1.I[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]([F:30])([F:29])[F:28])[CH:21]=1>>[CH3:1][C@@H:2]1[CH2:8][N:7]([CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[C:6](=[O:18])[CH2:5][CH2:4][N:3]1[C:24]1[CH:25]=[CH:20][CH:21]=[C:22]([O:26][C:27]([F:28])([F:29])[F:30])[CH:23]=1

Participants

3

Reactant 2

HCID 27772931-Iodo-3-(trifluoromethoxy)benzeneHCID 66783071HCID 66783071, compound

Product 1

HCID 59159289HCID 59159289, compound

Procedure

The title compound was prepared from (R)-2-methyl-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one (Example 39E) and 1-iodo-3-trifluoromethoxy-benzene in analogy to example 33. MS: 414.4 (MH+).

Sources & evidence

ORD record
ord-14f94af7d767466d8d7f7812ebec6aa4
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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