Tetrabutylammonium Fluoride → HCID 66783250, compound

Participants

Reaction Steps

To a solution of 1-[3-(tert-butyl-diphenyl-silanyloxy)-1-methoxymethyl-propyl]-3-methyl-4-(3-trifluoromethyl-phenyl)-piperazin-2-one (139 mg, 0.23 mmol) in THF (3 mL) was added tetrabutylammonium fluoride solution (1 M in THF, 0.28 mL, 0.28 mmol) at 0° C., then after 2 h the reaction mixture was partitioned between sat. aq. NaHCO3 solution and EtOAc. The organic layer was washed with brine, dried (MgSO4), filtered, and evaporated. Chromatography (SiO2; EtOAc/MeOH 19:1) afforded the title compound (44 mg, 52%) as a colorless oil.

Provenance & Evidence