反应详情

In analogy to the procedure described in example 1H, (S)-4-benzyloxy-2-[4-(3,4-dichloro-phenyl)-3-methyl-7-oxo-[1,4]diazepan-1-yl]-butyric acid methyl ester and boron tribromide (after warming up the reaction to maximum to −5° C.) gave after precipitation CH2Cl2/n-pentane 78% of the title compound as a 71:29 mixture of the (R) and (S) diastereomers. Off-white foam, MS: 447.0 (M+OAc−, 2Cl).

1. temperatureafter warming up
2. customthe reaction to maximum to −5° C.)
3. customgave
4. customafter precipitation CH2Cl2/n-pentane 78% of the title compound
5. additionas a 71:29 mixture of the (R) and (S) diastereomers