HCID 66783407, compound → HCID 66783080, compound

HRID 1096275Notes

Reaction equation

HRID 1096275 reaction equation
C(OC(=O)[NH:10][CH2:11][CH2:12][CH2:13][N:14]1[CH2:21][CH2:20][C:17]2([CH2:19][CH2:18]2)[C@H:16]([OH:22])[CH2:15]1)C1C=CC=CC=1>CO.[Pd]>[NH2:10][CH2:11][CH2:12][CH2:13][N:14]1[CH2:21][CH2:20][C:17]2([CH2:19][CH2:18]2)[C@H:16]([OH:22])[CH2:15]1

Participants

4

Reactant 1

HCID 66783407HCID 66783407, compound

Product 1

HCID 66783080HCID 66783080, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of [3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-carbamic acid benzyl ester (590 mg, 1.85 mmol) in MeOH (14 mL) was stirred under a hydrogen atmosphere (1 bar) in the presence of palladium (10% on activated charcoal, 200 mg), then after 90 min insoluble material was removed by filtration and the filtrate evaporated to afford the title compound (303 mg, 89%). Yellow liquid, MS: 185.2 (M+H)+.

Workup

  1. customafter 90 min insoluble material was removed by filtration
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-dbb08a2818404537b579a8deef3c08ea
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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