Ethanol → HCID 66783309, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-6-(3-amino-propyl)-6-aza-spiro[2.5]octan-4-ol (200 mg, 1.09 mmol), bromoacetaldehyde (183 mg, 1.09 mmol), potassium carbonate (300 mg, 2.17 mmol), and EtOH (2.5 mL) was heated at 150° C. for 20 min under microwave irradiation, then insoluble material was removed by filtration and the filtrate evaporated to afford 224 mg of a 60:40 mixture of the title compound and the tertiary amine (S)-6-{3-[bis-(2,2-dimethoxy-ethyl)-amino]-propyl}-6-aza-spiro[2.5]octan-4-ol, which was directly used in the next step. Yellow gum, MS: 273.2 (M+H)+.

Provenance & Evidence